Placental thrombomodulin expression in recurrent miscarriage

Placental thrombomodulin expression in recurrent miscarriage

BACKGROUND Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it's also a cofactor of the protein C anticoagulant pathway. DISCUSSION We evaluate the Thrombomodulin expression in placental tissue from spon...

Placental gene expression patterns during normal pregnancy and recurrent miscarriage

Increased placental expression and maternal serum levels of apoptosis-inducing TRAIL in recurrent miscarriage

INTRODUCTION Recurrent miscarriage (RM; ≥3 consecutive pregnancy losses) occurs in 1-3% of fertile couples. No biomarkers with high predictive value of threatening miscarriage have been identified. We aimed to profile whole-genome differential gene expression in RM placental tissue, and to determine the protein levels of identified loci in maternal sera in early pregnancy. METHODS GeneChips (...

Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriage.

BACKGROUND Recurrent miscarriage (RM) has been suggested to be caused by mutations in genes coding for various coagulation factors resulting in thrombophilia. Mouse models indicate that genes involved in the protein C anticoagulant pathway are essential for normal embryonic development. Loss of function of two of these genes, thrombomodulin (TM) and endothelial protein C receptor (EPCR), causes...

Recurrent miscarriage

Recurrent miscarriages are one or more pregnancy losses before 20-24 weeks of gestation or below a fetal weight of 500 g (Pic. 1). About 1% of women in reproductive age are affected by recurrent miscarriages. The majority of patients are counseled to try to conceive again, and chances are about 60% that the next pregnancy is successful without treatment. However, each additional loss worsens th...